Resource Type

Journal Article 15

Year

2023 3

2021 1

2020 2

2017 1

2016 1

2012 1

2009 1

2007 2

2004 1

2001 1

open ︾

Keywords

FLT3 inhibitors 1

AMLTargeted therapy 1

Beam pointing control 1

Circular stepped beam shape 1

Deployable mechanism 1

Field coupling theoretical model 1

Full-link and full-system Beam collection efficiency 1

Gilteritinib 1

Large modulation depth 1

Midostaurin 1

Near unity absorption 1

OMEGA-SSPS 1

Optical transparent 1

Optimization design 1

Parallel computing 1

Prototype 1

Quizartinib 1

Reusable launch vehicle (RLV) 1

Smart structure 1

open ︾

Search scope:

排序： Display mode:

Study on four-step operational mode prototype debugging of TGP lock under impounded level 156 m in the

Hu Ya’an,Zhang Ruikai,Li Yun

Strategic Study of CAE 2009, Volume 11, Issue 9,   Pages 52-58

Abstract: After adopting the optimizing water conveyance pattern by means of prototype debug, the cavitation of

Keywords： TGP lock     operational mode     prototype debugging    

HTML PDF Collect

Heave Compensation Equipment Virtual Prototype Cooperative Design and Simulation Analysis

Lü Dong,He Jiangsan,Liu Shaojun,Huang Kai

Strategic Study of CAE 2004, Volume 6, Issue 3,   Pages 36-40

Abstract:

This paper builds virtual prototype of heave compensation equipment by means of parameterized, concurrent

Keywords： heave compensation     virtual prototype     cooperative design     simulation    

HTML PDF Collect

Review on New Theories and Methods in Prototype Back Analysis of Dam

Gu Chongshi,Wu Zhongru

Strategic Study of CAE 2001, Volume 3, Issue 8,   Pages 76-81

Abstract:

Based on the study of the present theories and application in prototype back analysis of dam, the

Keywords： dam     prototype back analysis     application    

HTML PDF Collect

On the Innovation, Design, Construction, and Experiments of OMEGA-Based SSPS Prototype: The Sun Chasing Article

Baoyan Duan, Yiqun Zhang, Guangda Chen, Ze Zhao, Jianwei Mi, Xun Li, Lin Yang, Xi Li

Engineering doi: 10.1016/j.eng.2023.11.007

Abstract:

 

This study systematically introduces the development of the world's first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite (SSPS). First, the OMEGA 2.0 innovation design was proposed. Second, field-coupling theoretical models of sunlight concentration, photoelectric conversion, and transmitting antennas were established, and a systematic optimization design method was proposed. Third, a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was proposed. Fourth, a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the rectenna. Fifth, a high-efficiency heat radiator design method based on bionics and topology optimization was proposed. Sixth, a method for improving the rectenna array’s reception, rectification, and direct current (DC) power synthesis efficiencies is presented. Seventh, high-precision measurement technology for high-accuracy beam-pointing control was developed. Eighth, a smart mechanical structure was designed and developed. Finally, the developed SSPS ground demonstration and verification system has the capacity for sun tracking, a high concentration ratio, photoelectric conversion, microwave conversion and emission, microwave reception, and rectification, and thus satisfactory results were obtained.

Keywords： OMEGA-SSPS     Full-link and full-system Beam collection efficiency     Circular stepped beam shape     Smart structure     Field coupling theoretical model     Beam pointing control    

HTML PDF Collect

Biological chip technology to quickly batch select optimum cryopreservation procedure

YU Lina, LIU Jing, ZHOU Yixin, HUA Zezhao

Frontiers in Energy 2007, Volume 1, Issue 3,   Pages 316-321 doi: 10.1007/s11708-007-0046-2

Abstract: Prototype devices were fabricated and corresponding experimental tests were performed.

Keywords： idealistic cryoprotective     concentration     Prototype     technology     alternative    

HTML PDF Collect

A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 308-314 doi: 10.1007/s11709-017-0405-y

Abstract: An engineering example is used to illustrate the debugging process of asphalt mixture batching & mixing

Keywords： asphalt mixture     target mixing ratio     mix design implementation     batching & mixing plant debugging    

HTML PDF Collect

A prototype online database-enabled design framework for wind analysis/design of low-rise buildings

Dae Kun KWON,Ahsan KAREEM,Deepak KUMAR,Yukio TAMURA

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1,   Pages 121-130 doi: 10.1007/s11709-015-0329-3

Abstract: This study presents a development of an advanced cyberbased database-enabled design module for low-rise buildings (DEDM-LR) which provides estimation of the wind-induced responses for main wind force resisting frames by making direct use of pressure time histories measured at a large number of pressure taps over a suite of building models. These responses may be considered in lieu of code-specified load effects in which the overall accuracy may be influenced by the inherent simplifications in codes. In addition, this new automated approach is particularly attractive and advantageous as it allows a web-based online analysis/design via intuitive user-friendly interfaces for both the input and output in terms of familiar web-style forms that are nowadays very common in most of web-based services. Presently, the DEDM-LR hosts an aerodynamic database developed by the Tokyo Polytechnic University (TPU), Japan for a variety of building configurations like flat, gable, and hip roofs under suburban terrain flow condition with immediate application to other databases. The paper shows the efficacy and validity of the DEDM-LR by walking through its details and examples on selected gable-roofed buildings. The architecture of DEDM-LR platform offers the ability to pool resources by hosting other databases that may become available in the near future.

Keywords： wind loads     low-rise building     pressure measurement     aerodynamics     building design     structural response     building codes     information technology (IT)    

HTML PDF Collect

Prototype test study on mechanical characteristics of segmental lining structure of underwater railway

He Chuan,Feng Kun,Yan Qixiang,Qi Chun

Strategic Study of CAE 2012, Volume 14, Issue 10,   Pages 65-72

Abstract: of the first underwater railway shield tunnel, Guangzhou Zhujiang River Shiziyang shield tunnel, the prototype

Keywords： underwater railway shield tunnel     segmental lining structure     prototype test     tenon joint     failure characteristics    

HTML PDF Collect

Acoustic analysis of lightweight auto-body based on finite element method and boundary element method

LIANG Xinhua, ZHU Ping, LIN Zhongqin, ZHANG Yan

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 1,   Pages 99-103 doi: 10.1007/s11465-007-0017-7

Abstract: A lightweight automotive prototype using alternative materials and gauge thickness is studied by a numerical

Keywords： harshness     automotive prototype     structural optimization     vibration     efficient    

HTML PDF Collect

System construction of a four-side primary permanent-magnet linear motor drive mechanical press

Jintao LIANG, Zhengfeng MING, Peida LI

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 4,   Pages 600-609 doi: 10.1007/s11465-020-0597-z

Abstract: Then, a press prototype with 6 kN nominal force is fabricated, and the hardware platform of the control

Keywords： primary permanent-magnet linear motor (PPMLM)     servo system     active disturbance rejection control (ADRC)     prototype    

HTML PDF Collect

Transparent Thermally Tunable Microwave Absorber Prototype Based on Patterned VO2 Film Article

Zhengang Lu, Yilei Zhang, Heyan Wang, Chao Xia, Yunfei Liu, Shuliang Dou, Yao Li, Jiubin Tan

Engineering 2023, Volume 29, Issue 10,   Pages 198-206 doi: 10.1016/j.eng.2022.10.005

Abstract:

Transparent microwave absorbers that exhibit high optical transmittance and microwave absorption capability are ideal, although having a fixed absorption performance limits their applicability. Here, a simple, transparent, and thermally tunable microwave absorber is proposed, based on a patterned vanadium dioxide (VO2) film. Numerical calculations and experiments demonstrate that the proposed VO2 absorber has a high optical transmittance of 84.9% at 620 nm; its reflection loss at 15.06 GHz can be thermally tuned from –4.257 to –60.179 dB, and near-unity absorption is achieved at 523.75 K. Adjusting only the patterned VO2 film duty cycle can change the temperature of near-unity absorption. Our VO2 absorber has a simple composition, a high optical transmittance, a thermally tunable microwave absorption performance, a large modulation depth, and an adjustable temperature tuning range, making it promising for application in tunable sensors, thermal emitters, modulators, thermal imaging, bolometers, and photovoltaic devices.

Keywords： Tunable microwave absorber     VO2 film     Optical transparent     Near unity absorption     Large modulation depth    

HTML PDF Collect

Inhibition of FLT3: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia Review

Meira Yisraeli Salman, Jacob M. Rowe, Nir Weigert

Engineering 2021, Volume 7, Issue 10,   Pages 1354-1368 doi: 10.1016/j.eng.2021.05.020

Abstract:

Modern therapy of acute myeloid leukemia (AML) began in 1973 with the first report of the successful combination of daunorubicin and cytarabine, which led to complete remission in approximately 45% of patients. Accurate AML diagnosis was dependent on morphology, aided initially only by cytochemistry. Unlike acute lymphoblastic leukemia (ALL), immunophenotyping offered little in the diagnosis of AML, at least during the 1970s and 1980s. The advent of reliable cytogenetics changed the entire prognostic outlook of AML. With karyotypic analysis, different groups of AML could be classified and stratified for various therapies. Unique mutational profiling was a major advance in further categorizing AML patients, aided by the immunophenotypic identification of antigenic markers on the cells. All these advances were occurring as the understanding of the importance of the tumor burden—known as minimal residual disease (MRD)—became crucial for the management of AML patients. The efficacy of MRD has rapidly progressed in the past decade, from a specificity of 10−3 with immunophenotyping to 10−4 with polymerase chain reaction (PCR), which is only appropriate for some patients with AML, and finally to 10−5 or even 10−6 cells with the extraordinary sensitivity of next-generation sequencing (NGS). All of these advances have promoted the concept of personalized medicine, which has led to the advent of targeted agents that can accurately be used for specific diagnostic subtypes. Responses can be predicted and measured accurately. Such targeted agents have now become a cornerstone in the management of AML, increasing efficacy and dramatically reducing toxicity. The focus of this review is on one of the most well-studied targeted agents in AML: the FMS-like tyrosine kinase 3 (FLT3) inhibitors, which have impacted the prognostication and therapeutics of AML. This review selectively discusses the FLT3 inhibitors in detail, as a model for the other burgeoning targeted agents that have already been approved, as well as those that are currently in development.

Keywords： AMLTargeted therapy     FLT3 inhibitors     Midostaurin     Gilteritinib     Quizartinib     Sorafenib    

HTML PDF Collect

OHTMA: an optimized heuristic topology-aware mapping algorithm on the Tianhe-3 exascale supercomputer prototype Research Articles

Yi-shui Li, Xin-hai Chen, Jie Liu, Bo Yang, Chun-ye Gong, Xin-biao Gan, Sheng-guo Li, Han Xu,liyishui_lys@163.com,chenxinhai1995@aliyun.com,liujie@nudt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 6,   Pages 809-962 doi: 10.1631/FITEE.1900075

Abstract: Experimental results on the Tianhe-3 exascale supercomputer prototype indicate that OHTMA can significantly

Keywords： 高性能计算；拓扑映射；启发式算法    

HTML PDF Collect

Watt Linkage–Based Legged Deployable Landing Mechanism for Reusable Launch Vehicle: Principle, Prototype Article

Haitao Yu,Baolin Tian,Zhen Yan,Haibo Gao,Hongjian Zhang,Huiqiang Wu,Yingchao Wang,Yuhong Shi,Zongquan Deng

Engineering 2023, Volume 20, Issue 1,   Pages 120-133 doi: 10.1016/j.eng.2022.05.015

Abstract: Furthermore, the optimal scale parameters for guiding the LDLM prototype design is obtained numericallyA fully-functional scaled RLV prototype is developed by integrating the gravity-governed deploying scheme

Keywords： Reusable launch vehicle (RLV)     Deployable mechanism     Optimization design    

HTML PDF Collect

exascale supercomputing system: practice of a parallel supporting environment on the Sunway exascale prototype Research Article

Xiaobin HE, Xin CHEN, Heng GUO, Xin LIU, Dexun CHEN, Yuling YANG, Jie GAO, Yunlong FENG, Longde CHEN, Xiaona DIAO, Zuoning CHEN,hexiaobin_1984@163.com,ischen.xin@foxmail.com,yyylx@263.net,adch@263.net

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 1,   Pages 41-58 doi: 10.1631/FITEE.2200412

Abstract: Taking the exascale prototype system as an example, in this paper we first analyze the challenges ofthe optimization technologies used in the parallel supporting environment software on the exascale prototypehighlighted, including the parallel operating system, input/output (I/O) optimization technology, parallel debuggingsystems and I/O optimization technology mainly support large-scale system scaling, while the parallel debuggingFinally, the contributions to various applications running on the exascale prototype system are introduced

Keywords： Parallel computing     Sunway     Ultra-large-scale     Supercomputer    

HTML PDF Collect

Title Author Date Type Operation

Study on four-step operational mode prototype debugging of TGP lock under impounded level 156 m in the

Hu Ya’an,Zhang Ruikai,Li Yun

Journal Article

Heave Compensation Equipment Virtual Prototype Cooperative Design and Simulation Analysis

Lü Dong,He Jiangsan,Liu Shaojun,Huang Kai

Journal Article

Review on New Theories and Methods in Prototype Back Analysis of Dam

Gu Chongshi,Wu Zhongru

Journal Article

On the Innovation, Design, Construction, and Experiments of OMEGA-Based SSPS Prototype: The Sun Chasing

Baoyan Duan, Yiqun Zhang, Guangda Chen, Ze Zhao, Jianwei Mi, Xun Li, Lin Yang, Xi Li

Journal Article

Biological chip technology to quickly batch select optimum cryopreservation procedure

YU Lina, LIU Jing, ZHOU Yixin, HUA Zezhao

Journal Article

A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

Journal Article

A prototype online database-enabled design framework for wind analysis/design of low-rise buildings

Dae Kun KWON,Ahsan KAREEM,Deepak KUMAR,Yukio TAMURA

Journal Article

Prototype test study on mechanical characteristics of segmental lining structure of underwater railway

He Chuan,Feng Kun,Yan Qixiang,Qi Chun

Journal Article

Acoustic analysis of lightweight auto-body based on finite element method and boundary element method

LIANG Xinhua, ZHU Ping, LIN Zhongqin, ZHANG Yan

Journal Article

System construction of a four-side primary permanent-magnet linear motor drive mechanical press

Jintao LIANG, Zhengfeng MING, Peida LI

Journal Article

Transparent Thermally Tunable Microwave Absorber Prototype Based on Patterned VO2 Film

Zhengang Lu, Yilei Zhang, Heyan Wang, Chao Xia, Yunfei Liu, Shuliang Dou, Yao Li, Jiubin Tan

Journal Article

Inhibition of FLT3: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia

Meira Yisraeli Salman, Jacob M. Rowe, Nir Weigert

Journal Article

OHTMA: an optimized heuristic topology-aware mapping algorithm on the Tianhe-3 exascale supercomputer prototype

Yi-shui Li, Xin-hai Chen, Jie Liu, Bo Yang, Chun-ye Gong, Xin-biao Gan, Sheng-guo Li, Han Xu,liyishui_lys@163.com,chenxinhai1995@aliyun.com,liujie@nudt.edu.cn

Journal Article

Watt Linkage–Based Legged Deployable Landing Mechanism for Reusable Launch Vehicle: Principle, Prototype

Haitao Yu,Baolin Tian,Zhen Yan,Haibo Gao,Hongjian Zhang,Huiqiang Wu,Yingchao Wang,Yuhong Shi,Zongquan Deng

Journal Article

exascale supercomputing system: practice of a parallel supporting environment on the Sunway exascale prototype

Xiaobin HE, Xin CHEN, Heng GUO, Xin LIU, Dexun CHEN, Yuling YANG, Jie GAO, Yunlong FENG, Longde CHEN, Xiaona DIAO, Zuoning CHEN,hexiaobin_1984@163.com,ischen.xin@foxmail.com,yyylx@263.net,adch@263.net

Journal Article